DrugGen — Hardware Requirements & GPU Compatibility
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DrugGen is a 127M-parameter open language model from alimotahharynia. It supports a context window of up to 1,024 tokens. At Q4_K_M it needs about 0.08 GB of VRAM — see which GPUs and Macs can run it below.
Runs great on a 24 GB GPU
Runs from 8 GB (Q4_K_M)Best on 24 GB (Q4_K_M · ~8190 tok/s)Macs from 8 GB (Q4_K_M · ~896 tok/s)
GPL 3.0
Reference GPU · RTX 4090 24 GB
Estimates, ±20% · how we estimate
Run DrugGen
One recommended way. Every other method, OS and quant is in the step-by-step guide.Each way opens a step-by-step guide for your OS and quant.
Recommended
vllm serve alimotahharynia/DrugGen --max-model-len 1024vLLM repo with its own quantisation
Download: Weights on Hugging Face
Ways to runOther ways
each opens step-by-stepRun in cloud
Runs on RTX 3080 Ti (12 GB) (11 GB headroom) · Q4_K_M
- Generation speed
- ~7413 tok/s
- generation speed
- Cost per 1M output tokens
- $0.0046
- per 1M output tokens
How Much VRAM Does DrugGen Need?
Select a quantization level; the listed hardware adheres to it.
| Quantization | VRAM | +32K | On RTX 4090 (reference) | |
|---|---|---|---|---|
| 0.1 GB | — | 2-bit · K-quant — 2-bit quantization with K-quant improvements | Fits: — context · ~10920 tok/s | |
| 0.1 GB | — | 3-bit medium — 3-bit medium quantization | Fits: — context · ~9360 tok/s | |
| 0.1 GB | — | 4-bit medium — 4-bit medium quantization — most popular sweet spot | Fits: — context · ~8190 tok/s | |
| 0.1 GB | — | 5-bit medium — 5-bit medium quantization — good quality/size tradeoff | Fits: — context · ~6552 tok/s | |
| 0.1 GB | — | 6-bit, very good — 6-bit quantization, very good quality | Fits: — context · ~5956 tok/s | |
| 0.1 GB | — | 8-bit, near-lossless — 8-bit quantization, near-lossless | Fits: — context · ~4680 tok/s | |
| 0.3 GB | — | 16-bit · bfloat — Brain floating point 16 — preferred for training | Fits: — context · ~2340 tok/s |
Selected Q4_K_M
4-bit medium quantization0.1GBat 1K context
- Weights
- 0.1 GB
- KV cache
- 0.0 GB
- Overhead
- 0.3 GB
Fits RTX 4090 (reference) · 23.9 GB free · ~8190 tok/s
≥50 tok/s needs ≥6 GB/s · RTX 5090 ~14560, RTX 3090 Ti ~8190
Which Hardware Can Run DrugGen?
Q4_K_M · 0.1 GBDrugGen (Q4_K_M) requires 0.1 GB of VRAM to load the model weights. For comfortable inference with headroom for KV cache and system overhead, 1+ GB is recommended. 52 GPUs can run it, including NVIDIA GeForce RTX 5090, NVIDIA GeForce RTX 3090 Ti. 163 devices with unified memory can run DrugGen, including Mac Studio (M3 Ultra, 256GB), Mac Studio (M3 Ultra, 512GB).
≤ 11 GB
≤ 11 GB tier →fits · 7.9 GB free · up to — ctx
16 GPUs · 1 Mac class · 2 device families
RTX 3080~6177Simulate output on RTX 3080RTX 2080 Ti~5005Simulate output on RTX 2080 TiRTX 3070 Ti~4942Simulate output on RTX 3070 TiM3*8 GB~896Simulate output on iMac 24" M3 (8 GB)Orin Nano~829Simulate output on NVIDIA Jetson Orin Nano 8GB (Super)iPhone~597Simulate output on iPhone 1720 GB
fits · 19.9 GB free · up to — ctx
1 GPU
RX 7900 XT~6000Simulate output on RX 7900 XT32–40 GB
fits · 31.9 GB free · up to — ctx
1 GPU · 3 Mac classes · 4 device families
RTX 5090~14560Simulate output on RTX 5090M5 Max36 GB~4025Simulate output on Mac Studio M5 Max (36 GB)M532 GB~1344Simulate output on MacBook Air 13" M5 (32 GB)Orin~1664Simulate output on NVIDIA Jetson AGX Orin 32GBSnapdragon X Elite (X1E-80-100)~1097Simulate output on Snapdragon X Elite Copilot+ PC
By VRAM tier · typical GPUs and Macs at Q4_K_M
Similar models
1| Model | Score | VRAM | tok/s | Why it is similar |
|---|---|---|---|---|
| SmolLM 135M Instruct FP32modularai | — | 0.4 GB | ~1524 | same size |
Specifications
- Publisher
- alimotahharynia
- Parameters
- 127M
- Architecture
- GPT2LMHeadModel
- Context Length
- 1,024 tokens
- Vocabulary Size
- 53,083
- Release Date
- 2024-11-20
- License
- GPL 3.0
Frequently Asked Questions
How much VRAM does DrugGen need?
DrugGen requires 0.1 GB of VRAM at Q4_K_M, or 0.3 GB at BF16.
VRAM = Weights + KV Cache + Overhead
Weights = 127M × 4.8 bits ÷ 8 = 0.1 GB
Fit ratings and hardware model lists check this model with room for a 16K-token context, which needs a little more memory.
VRAM usage by quantization
What's the best quantization for DrugGen?
For DrugGen, Q4_K_M (0.1 GB) offers the best balance of quality and VRAM usage. Q5_K_M (0.1 GB) provides better quality if you have the VRAM. The smallest option is Q2_K at 0.1 GB.
VRAM requirement by quantization
★ Recommended — best balance of quality and VRAM usage.
Can I run DrugGen on a Mac?
Yes — MacBook Air 13" M3 (8 GB) and 145 other Macs can run DrugGen. Apple Silicon uses unified memory, so the model shares RAM with the system. At Q4_K_M you need at least 0.1 GB of usable unified memory (RAM minus macOS overhead).
Can I run DrugGen locally?
Yes — DrugGen can run locally on consumer hardware. Popular tools include Ollama, LM Studio, and llama.cpp.
How fast is DrugGen?
At Q4_K_M, DrugGen can reach ~60000 tok/s on AMD Instinct MI350X. On NVIDIA GeForce RTX 4090: ~8190 tok/s. Speed depends mainly on GPU memory bandwidth. Real-world results typically within ±20%.
tok/s = (bandwidth GB/s ÷ model GB) × efficiency
Example: NVIDIA B200 → 8000 ÷ 0.08 × 0.65 = ~65000 tok/s
Estimated speed at Q4_K_M (0.1 GB)
Real-world results typically within ±20%. Speed depends on batch size, quantization kernel, and software stack.
What's the download size of DrugGen?
At Q4_K_M, the download is about 0.08 GB. The full-precision BF16 version is 0.25 GB. The smallest option (Q2_K) is 0.05 GB.
Which GPUs can run DrugGen?
52 consumer GPUs can run DrugGen at Q4_K_M. Top options include AMD Radeon RX 6700 XT, AMD Radeon RX 6800, AMD Radeon RX 6800 XT. 52 GPUs have plenty of headroom for comfortable inference.
Which devices can run DrugGen?
163 devices with unified memory can run DrugGen at Q4_K_M (0.1 GB), including AMD Ryzen AI 9 HX 370 (Strix Point) Laptop, ASUS Ascent GX10, Beelink GTR9 Pro (Ryzen AI Max+ 395, 128 GB), Framework Desktop (Ryzen AI Max+ 395, 128 GB). Apple Silicon Macs use unified memory shared between CPU and GPU, making them well-suited for local LLM inference.